Journal
JOURNAL OF NEUROSCIENCE
Volume 40, Issue 16, Pages 3203-3216Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1553-18.2020
Keywords
calcium imaging; dopamine; lactation; network activity
Categories
Funding
- European Research Council ENDOSWITCH [261286]
- Swedish Research Council Vetenskapsradet
- Swedish Brain Foundation (Hjarnfonden)
- Strategic Research Program for Diabetes Research at Karolinska Institutet
- StratNeuro
- Novo Nordisk Fonden
- Vetenskapsradet
- Hjarnfonden
- Wenner-Gren Foundations Fellowship
- European Research Council (ERC) [261286] Funding Source: European Research Council (ERC)
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Giving birth triggers a wide repertoire of physiological and behavioral changes in the mother to enable her to feed and care for her offspring. These changes require coordination and are often orchestrated from the CNS, through as of yet poorly understood mechanisms. A neuronal population with a central role in puerperal changes is the tuberoinfundibular dopamine (TWA) neurons that control release of the pituitary hormone, prolactin, which triggers key maternal adaptations, including lactation and maternal care. Here, we used Ca2+ imaging on mice from both sexes and whole-cell recordings on female mouse TWA neurons in vitro to examine whether they adapt their cellular and network activity according to reproductive state. In the high-prolactin state of lactation, TIDA neurons shift to faster membrane potential oscillations, a reconfiguration that reverses upon weaning. During the estrous cycle, however, which includes a brief, but pronounced, prolactin peak, oscillation frequency remains stable. An increase in the hyperpolarization-activated mixed cation current, I-h, possibly through unmasking as dopamine release drops during nursing, may partially explain the reconfiguration of TIDA rhythms. These findings identify a reversible plasticity in hypothalamic network activity that can serve to adapt the darn for motherhood.
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