4.7 Article

Photoresponsive self-healing supramolecular hydrogels for light-induced release of DNA and doxorubicin

Journal

CHEMICAL COMMUNICATIONS
Volume 52, Issue 15, Pages 3143-3146

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc09633b

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Funding

  1. Deutsche Forschungsgemeinschaft (Graduiertenkolleg'') [GRK 2039, SFB 1176]

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An azobenzene-containing cyclic dipeptide PAP-DKP-Lys is a photoresponsive low-MW hydrogelator. The gelation process can be triggered with temperature, pH, light, and ionic strength. The resulting self-healing gels can encapsulate dsDNA or an anticancer drug doxorubicin, and release them in a light-dependent manner.

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