Journal
JOURNAL OF NEUROCHEMISTRY
Volume 155, Issue 6, Pages 602-611Publisher
WILEY
DOI: 10.1111/jnc.15039
Keywords
Alzheimer's disease; hormones; irisin; neurodegeneration; physical exercise
Categories
Funding
- Brazilian funding agency Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [434093/2018-1, 467546/2014-2]
- Brazilian funding agency FundacAo Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ) [202.744/2019, 202.944/2015]
- Brazilian funding agency National Institute for Translational Neuroscience (INNT/Brazil) [465346/2014-6]
- Alzheimer's Association [AARG-D-615741]
- International Society for Neurochemistry [CAEN 1B]
- Alzheimer's Society Canada
- Weston Brain Institute [ASCP365344, RR172188]
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The proportion of elderly populations is rapidly booming, and human lifespan has considerably increased in the past century because of scientific and medical advances. However, the winds of change brought by the 21st century made sedentarism one of the factors that renders the brain vulnerable to age-related chronic diseases, such as Alzheimer's disease (AD). Conversely, physical exercise has been shown to stimulate molecular mechanisms beneficial to cognition. Here, we review evidence showing the positive effects of physical exercise in the brain. We further discuss recent evidence that irisin, a myokine stimulated by physical exercise derived from fibronectin type III domain-containing protein 5 (FNDC5) transmembrane protein, has neuroprotective actions in the brain. Lastly, we highlight the importance of the crosstalk between the periphery and the brain in cognition and the therapeutic potential of FNDC5/irisin in AD.
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