Journal
JOURNAL OF NATURAL PRODUCTS
Volume 83, Issue 5, Pages 1701-1705Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b01251
Keywords
-
Funding
- Key R&D Project of Shandong Province [2018GSF118022]
- National Natural Science Foundation of China [21572154, 21772181, 81803344]
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1606403]
- Fundamental Research Funds for the Central Universities [201612013]
- Qingdao Scientific and Technological Innovation Center for Marine Biomedicine Development Grant [2017-CXZX01-1-1]
Ask authors/readers for more resources
The first total synthesis of isohericenone J is reported. Key features of this synthetic strategy are a Friedel-Crafts reaction to construct the isobenzofuranone unit and a Pd-catalyzed Stille coupling reaction for the formation of the C5-C1' bond, generating the natural product, as well as one of its isomers, in 6.0% overall yield in eight steps. This strategy provides a foundation for the synthesis of challenging isobenzofuranone and isoindolinone-type derivatives.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
