Journal
JOURNAL OF NATURAL PRODUCTS
Volume 83, Issue 5, Pages 1721-1724Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.0c00166
Keywords
-
Funding
- University of Auckland
Ask authors/readers for more resources
A short synthesis of the natural product polyaurine B is described. The 1,2,4-thiadiazole heterocycle was assembled using a Cu(II)-mediated heterocyclization reaction that forges the N-S bond. The final acylation step to install the methylcarbamate must be conducted under anhydrous, nonbasic conditions to prevent thiadiazole ring opening initiated by attack of hydroxide at C-5.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available