4.7 Article

Rh(III)-catalyzed chemoselective C-H functionalizations of tertiary aniline N-oxides with alkynes

Journal

CHEMICAL COMMUNICATIONS
Volume 52, Issue 37, Pages 6253-6256

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc02217k

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Funding

  1. National NSF of China [21432005, 21272160, 21321061]

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In this work, we report novel Rh(III)-catalyzed chemoselective functionalizations of tertiary aniline N-oxides with alkynes, including annulation via the sequential C(sp(2))-H and C(sp(3))-N activation for the formation of N-alkylindoles and an O-atom transfer (OAT) process for the synthesis of acetophenones.

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