Journal
JOURNAL OF NATURAL PRODUCTS
Volume 83, Issue 5, Pages 1641-1645Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.0c00147
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Funding
- National Natural Science Foundation of China [81872777]
- Education Foundation of Zhejiang Province [Y201329766]
- Science and Technology Plan Project of Lishui [2016RC04]
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Microeunicellols A (1) and B (2), two undescribed eunicellin diterpenoids, were isolated from the culture of a bacterial symbiont, Streptomyces albogriseolus SY67903. Their structures, including absolute configurations revealed by spectroscopic data and single-crystal X-ray diffraction analysis, are closely related with the diterpenoids from its host, a South China Sea gorgonian, Muricella sibogae. This is the first report of eunicellin diterpenoids, commonly coral-derived, from a bacterial symbiont of coral. The chemical metabolic relationship between the bacterium and its host is discussed. Biological evaluation revealed that compound 1 possessed cytotoxicities against several human cancer cell lines.
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