4.7 Article

Sequential Mukaiyama-Michael reaction induced by carbon acids

Journal

CHEMICAL COMMUNICATIONS
Volume 52, Issue 16, Pages 3280-3283

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc10115h

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Funding

  1. Kurata Memorial Hitachi Science and Technology Foundation
  2. PICS program
  3. Grants-in-Aid for Scientific Research [26105703, 26105755, 13J03764, 26460015] Funding Source: KAKEN

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In the presence of a strong carbon acid, the sequential Mukaiyama-Michael reaction using two different Michael acceptors proceeded and the reaction of ketene silyl acetal derived from EtOAc with alpha-pyrones as primal acceptors yielded the corresponding cyclic ketene silyl acetals, which were reactive enough to undergo the following reaction with second acceptors.

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