Journal
CHEMICAL COMMUNICATIONS
Volume 52, Issue 59, Pages 9224-9227Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc04011j
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Funding
- Max-Planck Society
- German Academic Exchange Service (DAAD)
- Ministerio de Economia y Competitividad [CTQ2013-43243-P, CTQ2015-71211-REDT]
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The preparation of a paramagnetic chelator that serves as a platform for multicontrast MRI, and can be utilized either as a T-1-weighted, paraCEST or F-19 MRI contrast agent is reported. Its europium(III) complex exhibits an extremely slow water exchange rate which is optimal for the use in CEST MRI. The potential of this platform was demonstrated through a series of MRI studies on tube phantoms and animals.
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