Journal
CHEMICAL COMMUNICATIONS
Volume 52, Issue 89, Pages 13163-13166Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc07394h
Keywords
-
Categories
Funding
- National Basic Research Program of China [(973)-2015CB856603]
- National Natural Science Foundation of China [20472096, 21372241, 21361140350, 20672127, 21421091, 21372250, 21121062, 21302203, 20732008, 21572052]
Ask authors/readers for more resources
Copper-catalyzed cascade cyclization of 1,5-enynes with two types of hypervalent reagents was developed via consecutive trifluoromethylazidation/diazidation and intramolecular click reaction (CUAAC), providing one-pot self-assembly of triazole fused isoindolines bearing a trifluoromethyl or an azide moiety. Moreover, the construction of a trifluoromethylcyclopropyl unit, which has been considered as a metabolically stable replacement for a tert-butyl moiety and was difficult to access, was also achieved under trifluoromethylazidation conditions. All these reactions exhibited excellent chemoselectivity, good to excellent yields and broad functional group tolerance.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available