Journal
CHEMICAL COMMUNICATIONS
Volume 52, Issue 3, Pages 521-524Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc05342k
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- CSIR
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Perfluoro undecanoyl chain conjugated peptide nucleic acids (PNAs) show 2.5 to 3 fold higher cellular uptake efficiency in NIH 3T3 and HeLa cells compared to simple undecanoyl PNAs. Fluorination of PNAs leads to the formation of lower size (similar to 100-250 nm) nanoparticles compared to larger size (similar to 500 nm) nanoparticles from non-fluorinated PNAs, thereby improving the efficiency of cell penetration.
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