Journal
JOURNAL OF MOLECULAR STRUCTURE
Volume 1206, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.molstruc.2020.127683
Keywords
Sn(IV) complex; Structural peculiarity; Anticancer activity; DNA interaction; Antimicrobial activity; Antileishmanial activity
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Funding
- Higher Education Commission Pakistan [6796/KPK/NRPU/RD/HEC/2016]
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This article focus on the synthesis of three 5-coordinated Sn(IV) complexes based on carboxylate ligand: 4-((4-methoxy-2-nitrophenyl)amino)-4-oxobutanoic acid. The complexes were characterized both in solid state (FT-IR, single crystal XRD and micro elemental analysis) as well as in solution state (H-1, C-13 and Sn-119 NMR) and their results demonstrate that the carboxylate moiety of the ligand is linked with Sn atom. A 5-coordinated trigonal bipyramidal structure was obtained from crystallographic data for the reported complexes with little bit distortion from the ideal structure. Preliminary antifungal screening showed that the tested compounds have 100% fungal inhibition capability as shown by the well known antifungal drug, Terbinafine. Bacterial inhibition results showed that these compounds have outstanding inhibition capability against various pathogens as compared to the market available standard antibacterial drugs, Cefixime and Roxithromicine. The antiproliferative/anticancer result against H157 cancer cell line revealed that compounds 1 and 2 have shown the maximum activity (49-69% cytotoxicity even at 2 mu g/mL final concentration). The tested compounds were found active against human corneal epithelial cells (HCEC). The synthesized compounds were almost non-toxic towards HCEC. Compounds 1 and 2 have shown 6.9% and 7.9% antiproliferative activity, respectively when used at the 2.0 mu g/mL final concentration while compound 3 is totally non-toxic towards HCEC like the standard drug, Methotrexate. The antileishmanial results of these compounds are good though their activity is lower than that of the Amphotericin B. An intercalative mode of interaction was observed during the interaction of the titled compounds with DNA. (C) 2020 Elsevier B.V. All rights reserved.
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