4.7 Article

Visible-light-mediated radical oxydifluoromethylation of olefinic amides for the synthesis of CF2H-containing heterocycles

Journal

CHEMICAL COMMUNICATIONS
Volume 52, Issue 91, Pages 13413-13416

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc07771d

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Funding

  1. National Natural Science Foundation of China [U1204205, 21202078]
  2. Program for Innovative Research Team (in Science and Technology) in the University of Henan Province [14IRTSTHN008]
  3. Innovation Scientists and Technicians Troop Construction Projects of Henan Province [154100510015]

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The visible-light-mediated oxydifluoromethylation of olefinic amides with difluoromethyl sulfones has been explored. This method allows for an efficient and practical synthesis of a variety of CF2H-containing benzoxazines and oxazolines bearing various functional groups under mild conditions.

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