Journal
JOURNAL OF MOLECULAR NEUROSCIENCE
Volume 70, Issue 8, Pages 1244-1254Publisher
SPRINGERNATURE
DOI: 10.1007/s12031-020-01533-8
Keywords
Post-stroke cognitive impairment (PSCI); Biomarkers; Inflammation; Oxidative damage
Categories
Funding
- scientific research of ShanghaiMunicipal Health Bureau [201940031]
- Leading Personnel Training Project of Shanghai Pudong New District Municipal Health Bureau [PWR12018-04]
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Post-stroke cognitive impairment (PSCI), as one of the major complications after stroke, refers to a series of syndromes from mild cognitive impairment to dementia caused by stroke. Stroke has been reported to increase the risk of cognitive impairment by at least five to eight times. The assessment of PSCI usually relies on neuropsychological tests, but the results of these tests are subjective and inaccurate, and can be insufficient for the diagnosis and prognosis of PSCI. In recent years, an increasing number studies have indicated that changes in the expression of biomarkers such as C-reactive protein (CRP), interleukin 6 (IL-6) and IL-10 in blood, urine and other body fluids are associated with cognitive decline after stroke. Therefore, the detection of biomarkers in circulating blood serum, plasma and cerebrospinal fluid (CSF) may improve the accuracy of diagnosis and prognosis in PSCI. This review aims to summarize the studies on potential molecular biomarkers of PSCI.
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