Journal
CHEMICAL COMMUNICATIONS
Volume 52, Issue 11, Pages 2322-2325Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc08883f
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Funding
- Ministry of Science and Technology, Taiwan [104-2113-M-033-009-MY2]
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A highly enantioselective organocatalytic vinylogous aldol-cyclization cascade reaction of 3-alkylidene oxindoles to isatins has been achieved by using bifunctional organocatalysts. The unexpected intramolecular lactonization which follows the initial aldol reaction, leading to the cleavage of the oxindole ring and generation of enantioenriched spirooxindole dihydropyranones in good to excellent yields with high enantioselectivities.
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