Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 432, Issue 15, Pages 4270-4286Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2020.04.015
Keywords
genome organization; nuclear architecture; liquid-liquid phase separation; intrinsically disordered protein region; RNA repeats
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Funding
- Deutsche Forschungsgemeinschaft (DFG) [2191, RI1283/16-1]
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Repetitive RNA (repRNA) sequences emerge as important regulators of the dynamic organization of genomic loci into membrane-less subcompartments with distinct nuclear functions. These domains include sites of active transcription like the nucleolus as well as (peri)centromeric and telomeric satellite repeats. Recent studies point to an important role of repRNAs in complex with proteins to promote a phase separation-driven formation of chromatin domains. We review how key features of the phase separation process can be revealed by different experimental approaches and discuss the associated structure-function relationships for chromatin subcompartments that involve repRNA. (C) 2020 The Authors. Published by Elsevier Ltd.
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