Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 432, Issue 14, Pages 3981-3986Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2020.03.018
Keywords
transcription; translation; ppGpp; Rho; premature transcription termination
Categories
Funding
- National Institutes of Health [GM072528]
- National Science Foundation [MCB-1614990]
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In bacteria, the rates of transcription elongation and translation elongation are coordinated, changing together in response to growth conditions. It has been proposed that this is due to physical coupling of RNA polymerase and the lead ribosome on nascent mRNA, an interaction important for preventing premature transcription termination by Rho factor. Recent studies challenge this view and provide evidence that coordination is indirect, mediated in Escherichia coli by the alarmone (p)ppGpp. Here, we discuss these new findings and how they shape our understanding of the functional relationship between RNA polymerase and the ribosome as well as the basis of transcriptional polarity. (C) 2020 Elsevier Ltd. All rights reserved.
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