Journal
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
Volume 30, Issue 10, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1361-6439/ab8e91
Keywords
planar microelectrode arrays; three-dimensional microelectrode arrays; electrogenic cell applications; in vitroassays
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Funding
- University of Central Florida
- BRIDG/Massey through an industrial collaborative project [1065604]
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The development of microelectrode arrays (MEAs) along with complementary advances in electronics, mechanics and software to connect with these arrays has led to thein vitrointerfacing and benchtop electrophysiological models of several electrically active cells such as neurons and cardiomyocytes proving vital models and testing of human disease conditions in a dish/on a chip. This topical review deals with the micro/nanofabrication technology development of Microelectrodes Arrays from early silicon based developments to today's additive manufacturing technologies that have been employed to address bio-micro-electro-mechanical systems tool development in this space. Specifically 2D and 3D MEAs technologies have been reviewed in this paper along with a broad overview of some of the biological applications using these devices that are advancing the very state of biomedical research.
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