4.7 Article

Durable proteo-hybrid vesicles for the extended functional lifetime of membrane proteins in bionanotechnology

Journal

CHEMICAL COMMUNICATIONS
Volume 52, Issue 73, Pages 11020-11023

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc04207d

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Funding

  1. Marie Curie Career Integration Grant BioNanoMuTT [PCIG09-GA-2011-293643]
  2. University of Leeds
  3. European Research Council under the European Union [280518]

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The full capabilities of membrane proteins in bionanotechnology can only be realised through improvements in their reconstitution environments that combine biocompatibility to support function and durability for long term stability. We demonstrate that hybrid vesicles composed of natural phospholipids and synthetic diblock copolymers have the potential to achieve these criteria.

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