4.7 Article

Incorporation and visualization of azido-functionalized N-oleoyl serinol in Jurkat cells, mouse brain astrocytes, 3T3 fibroblasts and human brain microvascular endothelial cells

Journal

CHEMICAL COMMUNICATIONS
Volume 52, Issue 55, Pages 8612-8614

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc02879a

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Funding

  1. Deutsche Forschungsgemeinschaft [RU2123]
  2. NIH [R01 R01AG034389, R56NS095215]

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The synthesis and biological evaluation of azido-N-oleoyl serinol is reported. It mimicks biofunctional lipid ceramides and has shown to be capable of click reactions for cell membrane imaging in Jurkat and human brain microvascular endothelial cells.

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