4.7 Article

A fluorescent surrogate of thymidine in duplex DNA

Journal

CHEMICAL COMMUNICATIONS
Volume 52, Issue 25, Pages 4718-4721

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc09552b

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T-DMA is a new fluorescent thymidine mimic composed of 2'-deoxy-uridine fused to dimethylaniline. T-DMA exhibits the same pK(a) and base pairing characteristics as native thymidine residues, and its fluorescence properties are highly sensitive to nucleobase ionization, base pairing and metal binding.

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