Journal
CHEMICAL COMMUNICATIONS
Volume 52, Issue 6, Pages 1194-1197Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc09181k
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Funding
- National Basic Research Program of China [2015CB755500]
- National Natural Science Foundation of China [51225305, U1401242, 51373203, 21174166]
- Natural Science Foundation of the Guangdong Province [2014A030312018, S2012020011070]
- Guangdong Innovative and Entrepreneurial Research Team Program [2013S086]
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A novel siRNA delivery system based on a triblock copolymer with pH and reduction dual-sensitivity was introduced. The polyplex, having high delivery efficiency not dependent on surface charge reversion in response to the pH value of tumor tissue, was used for target gene silencing in cancer therapy.
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