Journal
CHEMICAL COMMUNICATIONS
Volume 52, Issue 11, Pages 2342-2345Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc09973k
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Funding
- National Basic Research Program of China [2014CB542300]
- National Natural Science Foundation of China [21372115, 21572102, 21302093]
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A photo-click reaction was used as an efficient method to construct two-photon fluorescent probes bearing two functional peptides for targeting and for protease cleavage respectively. The activatable two-photon probe constructed by this method was applied to two-photon imaging of caspase-3 both in cellular apoptosis and in tumor tissue.
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