4.7 Article

Asymmetric sequential Au(I)/chiral tertiary amine catalysis: an enone-formation/cyanosilylation sequence to synthesize optically active 3-alkenyloxindoles from diazooxindoles

Journal

CHEMICAL COMMUNICATIONS
Volume 52, Issue 20, Pages 3943-3946

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc00333h

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Funding

  1. 973 program [2015CB856600]
  2. NSFC [21472049]
  3. Ministry of Education (PCSIRT)

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An unprecedented sequential gold-catalyzed enone-formation and bifunctional tertiary amine mediated asymmetric cyanosilylation reaction is developed, allowing the highly enantioselective synthesis of 3-alkenyloxindoles from diazooxindoles, furans and trimethylsilyl cyanide (TMSCN).

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