4.7 Article

In vivo monitoring of local pH values in a live rat brain based on the design of a specific electroactive molecule for H+

Journal

CHEMICAL COMMUNICATIONS
Volume 52, Issue 18, Pages 3717-3720

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc09540a

Keywords

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Funding

  1. NSFC [21175098, 21305104]
  2. National Nature Science Fund for distinguished Yong Scholars [21325521]
  3. Program of Shanghai Academic Research Leader [15XD1501600]

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pH plays an important role in the biochemical, ion-regulatory, or electrical machinery of nerve and glial cells, and is considered to be related to a number of degenerative diseases. Herein, we first develop a two-channel electrochemical ratiometric biosensor for local pH determination in a live rat brain, and report the accurate pH values in the different regions of live brains upon global cerebral ischemia.

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