Journal
CHEMICAL COMMUNICATIONS
Volume 52, Issue 37, Pages 6284-6287Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc00051g
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Funding
- Natural Science Foundation of China [21406196, 21576234]
- National High Technology Research and Development Program (863 Program) of China [SS2015AA020601]
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The structure-guided rational design of an NADH-dependent short-chain dehydrogenase/reductase (SDR) reversed the stereoselectivity towards halogenated acetophenones from Prelog to anti-Prelog. The enzyme-substrate interactions involving an aromatic ring and a halogen atom were proven to play critical roles in determining the stereoselectivity of these ketone reductions besides the steric repulsion.
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