4.7 Article

A versatile two-photon fluorescent probe for ratiometric imaging E. coli beta-galactosidase in live cells and in vivo

Journal

CHEMICAL COMMUNICATIONS
Volume 52, Issue 53, Pages 8283-8286

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc04373a

Keywords

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Funding

  1. NSFC [21533010, 91227126]
  2. National Key Scientific Instrument and Equipment Development Project of China [2013YQ17046307]
  3. Nature Science Foundation of Liaoning Province, China [2013020177]

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We have described the design, synthesis, spectroscopy and biological applications of NI-beta Gal, a versatile fluorescent probe to detect E. coli beta-galactosidase in live cells and mice sensitively and directly, which holds great promise for its application in biomedical research such as gene therapy for cancer in the future.

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