Journal
CHEMICAL COMMUNICATIONS
Volume 52, Issue 34, Pages 5832-5835Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc00898d
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Funding
- CAPES-Brazil/PVE-Program
- CAPES-Brazil/PDSE scholarship [7537/13-1]
- National Institute of General Medical Sciences of the National Institutes of Health (NIH) [R01GM107146]
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Cocrystals of a weakly basic drug (nevirapine) with acidic coformers are shown to alter the solubility dependence on pH, and to exhibit a pH(max) above which a less soluble cocrystal becomes more soluble than the drug. The cocrystal solubility advantage can be dialed up or down by solution pH.
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