Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 222, Issue 2, Pages 203-205Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiaa272
Keywords
influence; nucleic acid detection; SARS-CoV-2; storage; throat swab
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Funding
- National Key Research and Development Program of China [2016YFD0500807]
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The detection of SARS-CoV-2 infection is the premise of quarantine. In many countries or areas, samples need to be shipped or inactivated before SARS-CoV-2 testing. In this study, we checked the influence of sample storage conditions on SARS-CoV-2 nucleic acid testing results, including sample inactivation time, storage temperature, and storage time. All of these conditions caused an increase in the cycle threshold values of the nucleic acid tests and led to the misclassification of at least 10.2% of positive cases as negative or suspected. The results highlight the importance of immediate testing of samples for SARS-CoV-2 nucleic acid detection.
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