Journal
JOURNAL OF INFECTION
Volume 81, Issue 2, Pages 183-189Publisher
W B SAUNDERS CO LTD
DOI: 10.1016/j.jinf.2020.04.041
Keywords
Rotavirus; Vaccines; Autoimmunity; Celiac Disease; Type 1 Diabetes
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Funding
- Instituto de Salud Carlos III: project GePEM [Instituto de Salud Carlos III(ISCIII)/PI16/01478/Cofinanciado FEDER]
- Instituto de Salud Carlos III: project DIAVIR [Instituto de Salud Carlos III(ISCIII)/DTS19/00049/Cofinanciado FEDER]
- Instituto de Salud Carlos III: project Resvi-Omics [Instituto de Salud Carlos III(ISCIII)/PI19/0103
- 9/Cofinanciado FEDER]
- Instituto de Salud Carlos III: project project ReSVinext [Instituto de Salud Carlos III(ISCIII)/PI16/01569/Cofinanciado FEDER]
- [Instituto de Salud Carlos III(ISCIII)/PI19/01090/Cofinanciado FEDER]
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Rotavirus, a major etiological agent of acute diarrhea in children worldwide, has historically been linked to autoimmunity. In the last few years, several physiopathological approaches have been proposed to explain the leading mechanism triggering autoimmunity, from the old concept of molecular mimicry to the emerging theory of bystander activation and break of tolerance. Epidemiological and immunological data indicate a strong link between rotavirus infection and two of the autoimmune pathologies with the highest incidence: celiac disease and diabetes. The role for current oral rotavirus vaccines is now being elucidated, with a so far positive protective association demonstrated. (C) 2020 The Author(s). Published by Elsevier Ltd on behalf of The British Infection Association.
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