Journal
CHEMICAL COMMUNICATIONS
Volume 52, Issue 74, Pages 11151-11154Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc05565f
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Funding
- BIODESIGN of the Europe Union
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We report a strategy to generate a self-healing and pH responsive hydrogel network between drug-loaded nanoparticles and natural polysaccharides via magnesium-bisphosphonate ligand interactions. The injectable drug depot disassembles in a tumor-specific environment, providing localized uptake of the nanoparticles, which is highly appreciated in drug delivery applications and manufacturing of drug-loaded biomaterials using a syringe-based deposition technique.
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