4.7 Article

EXAFS reveals two Mo environments in the nitrogenase iron-molybdenum cofactor biosynthetic protein NifQ

Journal

CHEMICAL COMMUNICATIONS
Volume 52, Issue 79, Pages 11811-11814

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc06370e

Keywords

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Funding

  1. ERC Starting Grant [205442]
  2. MINECO [BIO2014-59131-R]
  3. Midwestern University
  4. DOE OBER
  5. NIH
  6. [GM-65440]
  7. European Research Council (ERC) [205442] Funding Source: European Research Council (ERC)

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Mo and Fe K-edge EXAFS analysis of NifQ shows the presence of a [MoFe3S4] cluster and a second independent Mo environment that includes Mo-O bonds and Mo-S bonds. Both environments are relevant to FeMo-co biosynthesis and may represent different stages of Mo biochemical transformations catalyzed by NifQ.

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