Related references
Note: Only part of the references are listed.Inhibiting Wee1 and ATR kinases produces tumor-selective synthetic lethality and suppresses metastasis
Amirali B. Bukhari et al.
JOURNAL OF CLINICAL INVESTIGATION (2019)
Checkpoint Kinase 1 Inhibition Enhances Cisplatin Cytotoxicity and Overcomes Cisplatin Resistance in SCLC by Promoting Mitotic Cell Death
Wei-Hsun Hsu et al.
JOURNAL OF THORACIC ONCOLOGY (2019)
SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis
Guihua Wang et al.
NATURE CELL BIOLOGY (2019)
Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer
Triparna Sen et al.
CANCER DISCOVERY (2019)
Ataxia telangiectasia and Rad3-related inhibitors and cancer therapy: where we stand
Lin Mei et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)
SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication
Swagata Halder et al.
NATURE COMMUNICATIONS (2019)
Cancer statistics, 2019
Rebecca L. Siegel et al.
CA-A CANCER JOURNAL FOR CLINICIANS (2019)
Broad Spectrum Activity of the Checkpoint Kinase 1 Inhibitor Prexasertib as a Single Agent or Chemopotentiator Across a Range of Preclinical Pediatric Tumor Models
Caitlin D. Lowery et al.
CLINICAL CANCER RESEARCH (2019)
Coordinately Targeting Cell-Cycle Checkpoint Functions in Integrated Models of Pancreatic Cancer
Sejin Chung et al.
CLINICAL CANCER RESEARCH (2019)
SCFβ-TrCP ubiquitinates CHK1 in an AMPK-dependent manner in response to glucose deprivation
Ying Ma et al.
MOLECULAR ONCOLOGY (2019)
State-of-the-art strategies for targeting the DNA damage response in cancer
Patrick G. Pilie et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2019)
CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells
Gwenola Manic et al.
GUT (2018)
TRAF4-mediated ubiquitination of NGF receptor TrkA regulates prostate cancer metastasis
Ramesh Singh et al.
JOURNAL OF CLINICAL INVESTIGATION (2018)
Prexasertib, a cell cycle checkpoint kinase 1 and 2 inhibitor, in BRCA wild-type recurrent high-grade serous ovarian cancer: a first-in-class proof-of-concept phase 2 study
Jung-Min Lee et al.
LANCET ONCOLOGY (2018)
Deubiquitinating enzyme USP3 controls CHK1 chromatin association and activation
Yu-Che Cheng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
ATR/CHK1 inhibitors and cancer therapy
Zhaojun Qiu et al.
RADIOTHERAPY AND ONCOLOGY (2018)
PIWIL3/OIP5-AS1/miR-367-3p/CEBPA feedback loop regulates the biological behavior of glioma cells
Xiaobai Liu et al.
THERANOSTICS (2018)
The cell cycle checkpoint inhibitors in the treatment of leukemias
A. Ghelli Luserna di Rora et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2017)
Ataxin-3 promotes genome integrity by stabilizing Chk1
Yingfeng Tu et al.
NUCLEIC ACIDS RESEARCH (2017)
The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia
Alessandro Di Tullio et al.
NATURE COMMUNICATIONS (2017)
NSC30049 inhibits Chk1 pathway in 5-FU-resistant CRC bulk and stem cell populations
Satya Narayan et al.
ONCOTARGET (2017)
Gemcitabine and Chk1 Inhibitor AZD7762 Synergistically Suppress the Growth of Lkb1-Deficient Lung Adenocarcinoma
Yan Liu et al.
CANCER RESEARCH (2017)
CHK1 Inhibition in Small-Cell Lung Cancer Produces Single-Agent Activity in Biomarker-Defined Disease Subsets and Combination Activity with Cisplatin or Olaparib
Triparna Sen et al.
CANCER RESEARCH (2017)
Pharmacologic resistance in colorectal cancer: a review
William A. Hammond et al.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2016)
Leptin and insulin up-regulate miR-4443 to suppress NCOA1 and TRAF4, and decrease the invasiveness of human colon cancer cells
Ari Meerson et al.
BMC CANCER (2016)
Phase I Study of LY2606368, a Checkpoint Kinase 1 Inhibitor, in Patients With Advanced Cancer
David Hong et al.
JOURNAL OF CLINICAL ONCOLOGY (2016)
PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations
Weiping Zou et al.
SCIENCE TRANSLATIONAL MEDICINE (2016)
Targeting DNA Replication Stress for Cancer Therapy
Jun Zhang et al.
GENES (2016)
Phase I Dose-Escalation Trial of Checkpoint Kinase 1 Inhibitor MK-8776 As Monotherapy and in Combination With Gemcitabine in Patients With Advanced Solid Tumors
Adil I. Daud et al.
JOURNAL OF CLINICAL ONCOLOGY (2015)
In vitro and in vivo single-agent efficacy of checkpoint kinase inhibition in acute lymphoblastic leukemia
Ilaria Iacobucci et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2015)
Skp2-Dependent Ubiquitination and Activation of LKB1 Is Essential for Cancer Cell Survival under Energy Stress
Szu-Wei Lee et al.
MOLECULAR CELL (2015)
USP7 controls Chk1 protein stability by direct deubiquitination
Ignacio Alonso-de Vega et al.
CELL CYCLE (2014)
Roles of Chk1 in cell biology and cancer therapy
Youwei Zhang et al.
INTERNATIONAL JOURNAL OF CANCER (2014)
CHK1 plays a critical role in the anti-leukemic activity of the wee1 inhibitor MK-1775 in acute myeloid leukemia cells
Wenxiu Qi et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2014)
ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CH K1
Peijing Zhang et al.
NATURE CELL BIOLOGY (2014)
Improved vectors and genome-wide libraries for CRISPR screening
Neville E. Sanjana et al.
NATURE METHODS (2014)
MYC Regulation of CHK1 and CHK2 Promotes Radioresistance in a Stem Cell-like Population of Nasopharyngeal Carcinoma Cells
Wen-Jun Wang et al.
CANCER RESEARCH (2013)
TRAF4 Is a Critical Molecule for Akt Activation in Lung Cancer
Wei Li et al.
CANCER RESEARCH (2013)
TRAF4 Promotes TGF-β Receptor Signaling and Drives Breast Cancer Metastasis
Long Zhang et al.
MOLECULAR CELL (2013)
Candidate tumor suppressor BTG3 maintains genomic stability by promoting Lys63-linked ubiquitination and activation of the checkpoint kinase CHK1
Yu-Che Cheng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis
Chia-Hsin Chan et al.
CELL (2012)
Skp2 E3 Ligase Integrates ATM Activation and Homologous Recombination Repair by Ubiquitinating NBS1
Juan Wu et al.
MOLECULAR CELL (2012)
USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation
Jean-Hugues Guervilly et al.
HUMAN MOLECULAR GENETICS (2011)
The F Box Protein Fbx6 Regulates Chk1 Stability and Cellular Sensitivity to Replication Stress
You-Wei Zhang et al.
MOLECULAR CELL (2009)
The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation
Wei-Lei Yang et al.
SCIENCE (2009)
TRAF4 overexpression is a common characteristic of human carcinomas
S. Camilleri-Broet et al.
ONCOGENE (2007)
Specific role of Chk1 phosphorylations in cell survival and checkpoint activation
Hiroyuki Niida et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1)
Jiabin Tang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response
VAJ Smits et al.
CURRENT BIOLOGY (2006)
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
A Jazayeri et al.
NATURE CELL BIOLOGY (2006)
Depletion of Chk1 leads to premature activation of Cdc2-cyclin B and mitotic catastrophe
H Niida et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Genotoxic stress targets human Chk1 for degradation by the ubipuitin-proteasome pathway
YW Zhang et al.
MOLECULAR CELL (2005)
Share Paper
