4.7 Article

An enzyme-responsive controlled release system based on a dual-functional peptide

Journal

CHEMICAL COMMUNICATIONS
Volume 52, Issue 29, Pages 5112-5115

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc10480g

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Funding

  1. McKenzie fellowship
  2. ARC Dairy Innovation Hub [IH120100005]
  3. Australian Research Council [IH120100005] Funding Source: Australian Research Council

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A new controlled release system was developed by loading a dual-functional peptide (DFP) on a mesoporous silica material. One-pot synthesis produced a DFP that was stimuli responsive, releasing a therapeutic peptide by protease cleavage. The design provides new steps towards smart biomaterials.

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