Journal
JOURNAL OF GENETICS AND GENOMICS
Volume 47, Issue 11, Pages 659-671Publisher
SCIENCE PRESS
DOI: 10.1016/j.jgg.2020.04.003
Keywords
Aging; Oocyte; Aneuploidy; Cohesin; SAC; Spindle; Mitochondria; Meiosis; DNA damage
Funding
- National Natural Science Foundation of China [31801245, 81671425, 81971357]
- Key Research & Development Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory [2019GZR110104001]
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One of the main causes of pregnancy failure and fetus abortion is oocyte aneuploidy, which is increased with maternal aging. Numerous possible causes of oocyte aneuploidy in aged women have been proposed, including cross-over formation defect, cohesin loss, spindle deformation, spindle assembly checkpoint malfunction, microtubule-kinetochore attachment failure, kinetochore mis-orientation, mitochondria dysfunction-induced increases in reactive oxygen species, protein over-acetylation, and DNA damage. However, it still needs to be answered if these aneuploidization factors have inherent relations, and how to prevent chromosome aneuploidy in aged oocytes. Epidemiologically, oocyte aneuploidy has been found to be weakly associated with higher homocysteine concentrations, obesity, ionizing radiation and even seasonality. In this review, we summarize the research progress and present an integrated view of oocyte aneuploidization. Copyright (C) 2020, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. All rights reserved.
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