Journal
CHEMICAL COMMUNICATIONS
Volume 52, Issue 27, Pages 4894-4897Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc00890a
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Funding
- BMBF (GenBioCom in the GenoMik program)
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DNA-intercalating polyketide glycosides are important leads for cancer therapeutics, yet their use is often limited by their low solubility and challenging synthetic protocols. To overcome these limitations, we employed 1,4'-bipiperidine-1'-carbamate residues as sugar surrogates in daunorubicin and chartreusin, yielding water-soluble derivatives and prodrugs with dramatically improved antiproliferative activities.
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