Journal
CHEMICAL COMMUNICATIONS
Volume 52, Issue 11, Pages 2296-2299Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc09998f
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Funding
- Natural Science Foundation of China [21572093]
- Natural Science Foundation of Gansu Province [145RJZA225]
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The first off-on probe, Mito-TRFS, for imaging the mitochondrial thioredoxin reductase (TrxR2) in live cells was reported. In a cellular model of Parkinson's disease (PD), Mito-TRFS staining discloses a drastic decline of the TrxR2 activity, providing a mechanistic link of TrxR2 dysfunction to the etiology of PD.
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