Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 217, Issue 6, Pages -Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20200678
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Funding
- Burroughs Wellcome Fund Career Award for Medical Scientists
- Memorial Sloan-Kettering Cancer Center support grant [P30 CA008748]
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The novel 2019 strain of coronavirus is a source of profound morbidity and mortality worldwide. Compared with recent viral outbreaks, COVID-19 infection has a relatively high mortality rate, the reasons for which are not entirely clear. Furthermore, treatment options for COVID-19 infection are currently limited. In this Perspective, we explore the contributions of the innate and adaptive immune systems to both viral control as well as toxicity during COVID-19 infections and offer suggestions to both understand and therapeutically modulate anti-COVID immunity.
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