Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 217, Issue 5, Pages -Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20190347
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [17K15722, 17K10002]
- Astellas Foundation for Research on Metabolic Disorders
- Grants-in-Aid for Scientific Research [17K10002, 17K15722] Funding Source: KAKEN
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Interleukin-6 (IL-6) has been identified as a 26-kD secreted protein that stimulates B cells to produce antibodies. Later, IL-6 was revealed to have various functions that overlap with other IL-6 family cytokines and use the common IL-6 signal transducer gp130. IL-6 stimulates cells through multiple pathways, using both membrane and soluble IL-6 receptors. As indicated by the expanding market for IL-6 inhibitors, it has become a primary therapeutic target among IL-6 family cytokines. Here, we revisit the discovery of IL-6; discuss insights regarding the roles of this family of cytokines; and highlight recent advances in our understanding of regulation of IL-6 expression.
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