Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 217, Issue 4, Pages -Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20191865
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Funding
- National Institutes of Health [NS106668, NS102721]
- Cure Alzheimer's Fund
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Samuel I. Newhouse Foundation
- Rudin Family Foundation
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Plasminogen and its active form, plasmin, have diverse functions related to the inflammatory response in mammals. Due to these roles in inflammation, plasminogen has been implicated in the progression of a wide range of diseases with an inflammatory component. In this review, we discuss the functions of plasminogen in inflammatory regulation and how this system plays a role in the pathogenesis of diseases spanning organ systems throughout the body.
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