Journal
CHEMICAL COMMUNICATIONS
Volume 52, Issue 20, Pages 3883-3886Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc07868g
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Funding
- JSPS KAKENHI [24651261, 15K14943]
- System Instruments (Tokyo, Japan)
- Grants-in-Aid for Scientific Research [25286032, 15H01100, 24651261, 15K14943] Funding Source: KAKEN
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A synthetic polymer ligand-grafted plasmonic chip was fabricated and demonstrated a highly sensitive detection of C-reactive protein (CRP) by grating-coupled surface plasmon field-enhanced fluorescence. Poly(2-methacryloyloxyethyl-phosphorylcholine) was used as a CRP-specific polymer ligand layer and was grafted onto the plasmonic chip using surface-initiated controlled/living radical polymerization (limit of detection: ca. 10 pM).
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