Journal
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
Volume 39, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s13046-020-01570-6
Keywords
exosomal miRNAs; tumor microenvironment (TME); CAFs; angiogenesis; immune microenvironment
Categories
Funding
- National Natural Science Foundation of China [81972636, 81872281]
- Natural Science Foundation of Hunan Province [2019JJ40175, 2019JJ40183, 2018JJ1013, 2017JJ3190]
- Research Project of the Health and Family Planning Commission of Hunan Province [B20180400, B20180582]
- Changsha Science and Technology Board [kq1706045, kq1706043]
- Ascend Foundation of National cancer center [NCC2018b68]
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Tumor microenvironment (TME) is the internal environment in which tumor cells survive, consisting of tumor cells, fibroblasts, endothelial cells, and immune cells, as well as non-cellular components, such as exosomes and cytokines. Exosomes are tiny extracellular vesicles (40-160nm) containing active substances, such as proteins, lipids and nucleic acids. Exosomes carry biologically active miRNAs to shuttle between tumor cells and TME, thereby affecting tumor development. Tumor-derived exosomal miRNAs induce matrix reprogramming in TME, creating a microenvironment that is conducive to tumor growth, metastasis, immune escape and chemotherapy resistance. In this review, we updated the role of exosomal miRNAs in the process of TME reshaping.
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