4.7 Article

A novel anticancer theranostic pro-prodrug based on hypoxia and photo sequential control

Journal

CHEMICAL COMMUNICATIONS
Volume 52, Issue 60, Pages 9434-9437

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc02932a

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Funding

  1. Key Basic Research Special Foundation of Science Technology Ministry of Hebei Province [15962602D]
  2. Key Research Project Foundation of Department of Education of Hebei Province [ZH2012041]
  3. Natural Science Foundation of Hebei Province [B2015201213]

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A novel anticancer pro-prodrug (GMC-CAE-NO2) with diagnosis and therapy functions based on hypoxia and photo sequential control was designed. It provides a platform for constructing theranostic pro-prodrugs to release active drugs controlled by hypoxic status and UV illumination.

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