4.7 Article

Maleimide-assisted anti-Markovnikov Wacker-type oxidation of vinylarenes using molecular oxygen as a terminal oxidant

Journal

CHEMICAL COMMUNICATIONS
Volume 52, Issue 2, Pages 335-338

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc06746d

Keywords

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Funding

  1. Ministry of Education, Culture, Sports, Science, and Technology (MEXT), Japan [25410116]
  2. Grants-in-Aid for Scientific Research [25410116] Funding Source: KAKEN

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Arylacetaldehydes were successfully synthesized by the anti-Markovnikov Wacker-type oxidation of vinylarenes using 1 atm O-2 as a terminal oxidant under mild conditions. Electron-deficient alkenes, such as maleic anhydride and maleimides, were effective additives and would operate as ligands to stabilize the Pd(0) species during the reaction.

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