Journal
CHEMICAL COMMUNICATIONS
Volume 52, Issue 84, Pages 12454-12457Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc07110d
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Funding
- UK's Engineering and Physical Sciences Research Council (EPSRC) [EP/M506448/1, EP/H005285/1, EP/M028100/1]
- British Heart Foundation [PG/11/81/29130] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/M028100/1, 1371727, 955756, EP/H005285/1] Funding Source: researchfish
- EPSRC [EP/M028100/1, EP/H005285/1] Funding Source: UKRI
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We have developed self-assembled DNA mini-circles that contain a G-quadruplex-forming sequence from the c-Myc oncogene promoter and demonstrate by FRET that the G-quadruplex unfolding kinetics are 10-fold slower than for the simpler 24-mer G-quadruplex that is commonly used for FRET experiments.
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