Journal
JOURNAL OF CONTROLLED RELEASE
Volume 320, Issue -, Pages 1-18Publisher
ELSEVIER
DOI: 10.1016/j.jconrel.2020.01.007
Keywords
In situ regulation; Protein corona; Surface chemistry; Specific plasma protein adsorption; Disease-targeting therapy
Funding
- Anhui University of Chinese Medicine Foundation [2019zrzd13, 2020py04]
- Key Project of Anhui Province Department of Education [KJ2019A0471]
- Key Project of Liaoning Province Department of Education [2017LZD03]
- National Nature Science Foundation of China [81873019, 81873351, 81773656, U1608283]
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The protein corona significantly changes the nanoparticle (NP) identity both physicochemically and biologically, and in situ regulation of specific plasma protein adsorption on NP surfaces has emerged as a promising strategy for disease-targeting therapy. In the past decade, great progress in protein corona regulation has been achieved via surface chemistry-based nanomedicine development. This review first outlines the latest advances in bio-nano interactions, with special attention to factors that influence the protein corona, including NP physicochemical properties, the biological environment and the duration time. Second, NP surface chemistry strategies designed to inhibit and regulate protein corona formation are highlighted, with special emphasis on albumin, transferrin, apolipoprotein (apo) E, vascular endothelial growth factor (VEGF) and retinol binding protein 4 (RBP4). Finally, the current techniques used to characterize the protein corona are briefly discussed.
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