Journal
CHEMICAL COMMUNICATIONS
Volume 52, Issue 34, Pages 5860-5863Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc02221a
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Funding
- Boston University
- French National Agency (ANR) [Blanc SIMI 7-2010]
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Low molecular weight hydrogels, prepared from glycosyl-nucleoside-lipid amphiphiles, exhibit shear-thinning behaviour and reversible thermally-and mechanically-triggered sol-gel transitions. Using mechanical shear stimulation, the release of entrapped anti-TNF alpha increases and the released anti-TNF alpha demonstrates efficacy in in vitro neutralization bioassays. Delivery of anti-TNF alpha is of general interest and broad medicinal utility for treating autoimmune diseases such as rheumatoid arthritis.
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