Journal
CHEMICAL COMMUNICATIONS
Volume 52, Issue 34, Pages 5836-5839Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc02522f
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Funding
- UC Irvine
- National Institutes of Health [GM105938]
- Eli Lilly
- NSF Graduate Research Fellowship
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM105938] Funding Source: NIH RePORTER
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Herein, we describe a regioselective Rh-catalyzed decarboxylative cross-coupling of beta-keto acids and alkynes to access branched gamma,delta-unsaturated ketones. Rh-hydride catalysis enables the isomerization of an alkyne to generate ametal-allyl species that can undergo carbon-carbon bond formation. Ketones are generated under mild conditions, without the need for base or activated electrophiles.
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