Journal
CHEMICAL COMMUNICATIONS
Volume 52, Issue 20, Pages 3966-3969Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc00450d
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Funding
- National Natural Science Foundation of China [51303154, 51573160, 21574114]
- Key Science Technology Innovation Team of Zhejiang Province [2013TD02]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry [[2015]311]
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Novel 5-aminolevulinic acid (ALA) pseudopolyrotaxane prodrug micelles with dual pH-responsive properties were prepared by the host-guest interaction of alpha-cyclodextrin (alpha-CD) and poly(ethylene glycol) (PEG). The micelles exhibited pH dependent cellular uptake and pH-sensitive ALA release, enabling enhanced photodynamic therapy.
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