4.7 Article

Development and substrate specificity screening of an in vivo biosensor for the detection of biomass derived aromatic chemical building blocks

Journal

CHEMICAL COMMUNICATIONS
Volume 52, Issue 76, Pages 11402-11405

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc04559f

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Funding

  1. Biotechnology and Biological Sciences Research Council (BBSRC) grants [BB/L026244/1]
  2. Science without Borders/Ciencia sem fronteiras scheme from the CNPq, Brazil [233608/2014-1]
  3. BBSRC [BB/L026244/1, BB/M017702/1] Funding Source: UKRI
  4. Biotechnology and Biological Sciences Research Council [BB/M017702/1, BB/L026244/1] Funding Source: researchfish

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Measuring substrate and/or product concentration can create a major bottleneck for synthetic and biosynthetic processes. Here we report the development and substrate screening of a whole cell biosensor to detect biomass-derived aromatic chemical building blocks, supporting the use of sustainable feedstocks in the bulk and fine chemical industries.

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